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[3] At the cellular level, application of Semax at 1 M increased the frequency of spontaneous intracellular calcium fluctuations in hippocampal CA1 pyramidal neurons, one candidate substrate for its reported effects on neuronal signaling
Proceedings of the National Academy of Sciences of the United States of America, 107 (16), 74557460
However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal tract, the gut microbial communities and the tissue-resident immune cells
We also conducted studies in the SCD mouse model to gain additional evidence for this observation