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Ideal candidates are individuals who are close to their ideal body weight but have localized fat deposits that are resistant to diet and exercise

N Engl J Med 387(3):205216 Garvey WT, Frias JP, Jastreboff AM et al (2023) Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

This is the same mechanism that turns stools black during BSS use, which patients should be counseled about upfront

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Researchers investigation its role in molecular biology and physiological modeling