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While there is still limited available evidence, current knowledge suggests that semaglutide is able to reduce circulating inflammatory cytokines and modulate immune system responses

More specifically speaking, the mechanism potentially involved downregulation of macrophage CD11b, which played a vital role in monocyte adhesion, as well as decreased expression of macrophage modulators including CXCL-10, CXCL-1, C-C motif chemokine ligand-1 (CCL-2) and tissue inhibitor of metal protease-1 (TIMP-1) (Robinson et al., 2015)

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In dogs, supplementation has been associated with improved exercise performance and recovery in certain contexts, likely by supporting energy availability during activity

doi: 10.2337/dc15-0165 233 VosoughiKAtiehJKhannaLKhoshbinKProkopLJDavitkovPet al