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Dissociated hippocampal neurons were transfected with mRFP-p-actin and shMet RNA and receptor knock-down was allowed to take place for 48 hours prior to stimulating with 0.5 g (per well) HGF (10 ng/ml), Dihexa or Nlel -AnglV (both at 10 " 12 M)

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Both v6 and v8 integrins facilitate TGF activation by interacting with the RGD sequence present in the latent, inactive LAP (latency-associated peptide)-TGF complex

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