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However, GHK-Cu goes further by: Stimulating collagen more directly Enhancing tissue repair Reducing inflammation Vitamin C and GHK-Cu serve different purposes, so combination therapy with both usually works better

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They help promote collagen synthesis by activating fibroblasts, which is essential for rebuilding skin, tendons and joints

At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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