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Patients with a pre-existing seizure disorder or epilepsy should inform their healthcare provider before starting any weight loss medication, as metabolic changes associated with treatment could theoretically affect seizure threshold or interact with antiepileptic medications

Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding

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By contrast, M2-like macrophages, also called alternatively activated macrophages, are mainly associated with anti-inflammatory responses [81]