Commonly reported effects include nausea, diarrhea, and decreased appetite, wich may be transient but can affect quality of life
This study reported an A1c reduction of 1.5 2.2% within the full cohort, with the largest reductions seen in patients with a baseline A1c 12% ( n = 181
A multidisciplinary expert consensus published in Frontiers in Endocrinology recommends starting with osmotic laxatives (MiraLAX or magnesium) and only escalating to stimulant laxatives if osmotic options prove insufficient after 2-3 weeks of consistent use
Nelson (68) and provided after backcrossing with C57BL/6J by Klaus Schughart, Helmholtz Zentrum, Braunschweig, Germany
Better metrics to track weekly include waist circumference (more consistent than scale weight for body composition changes), appetite scores (rate your hunger and food cravings on a 1 to 10 scale each day), energy levels, sleep quality, side effect severity, and dietary intake patterns
Compared to a 4.3% mortality rate in the GLP-1RA group, the tirzepatide group saw a 2.4% mortality rate
