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Peripheral administration of liraglutide decreased preference for highly palatable foods in rats suggesting that GLP-1R mimetics may have therapeutic potential to decrease food reward (Raun et al., 2007
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Additionally, those taking thyroid replacement medication (levothyroxine) must monitor absorption, as GLP-1 induced slower gastric motility can reduce drug bioavailability and necessitate dose timing adjustments
Corroborating this hypothesis, HIF-1, a transcriptional factor known to target glycolytic genes, accumulates under GLP-1R stimulation