For now, the most accurate statement is that both treatments produce approximately 20 to 23% weight loss in non-diabetic populations with obesity, and both are in a class far beyond anything that came before them
Contrave (naltrexone HCL/bupropion HCL) and Xenical (orlistat) are also popular weight-loss medications
Higher dose / Wegovy HD (approved March 2026): The 7.2 mg injection, which demonstrated approximately 21% average weight loss over 72 weeks in the STEP UP trial, with over 90% of participants achieving at least 5% weight loss and about a third losing 25% or more
Enhanced appetite suppression sometimes causes researchers to eat too little protein, which can slow metabolism and reduce the thermic effect of food
According to the Ozempic (semaglutide) patient medication information pamphlet , stomach pain is a common side effect that impacts 1 in 10 patients who use Ozempic
Best Injection Site for Semaglutide Patients also ask best time to inject semaglutide or when is the best time to inject semaglutide. In addition to timing, site rotation and injection technique are important
