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however, Heart palpitations after exercise can be an indicator of dehydration or an electrolyte imbalance

These could be signs of a more serious underlying condition

"Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers." Planta Medica

A form of painful chronic thyroiditis with amyloid infiltration has also been described, and is probably etiologically distinct from Hashimoto's thyroiditis(100)

[1] However, because long-term safety data for low-dose oral MB is not robust, physicians generally proceed cautiously and will periodically re-evaluate the necessity of continuing

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