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In ATTAIN-1, adverse event-related discontinuation rates were 5.3% with orforglipron 6 mg, 7.6% with 12 mg, and 10.3% with 36 mg, compared with 2.7% with placebo

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IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is an 83-amino-acid synthetic variant of human IGF-1, engineered with two key structural modifications: a glutamic acid substitution for arginine at position 3 (R3) and a 13-amino-acid N-terminal extension peptide

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10.3389/fphys.2018.00830 176 YuY.LiR.PuL.PanC.GuoC.WangX