Taken together, these data demonstrate that CYP-driven bioconversion of APAP occurs in our model and augments mortality, thus recapitulating similar findings described in vertebrate models 31
Finally, we found that conditioned media of both CHO:MCD-treated SH-SY5Y cells and primary neuronal cells overexpressing SREBF2 exposed to A insult, completely abolished the enhanced phagocytic capacity of cholesterol-enriched microglia, which was likely due to the endogenous danger signals secreted or released after the A insult
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