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Sometimes small changes accumulate into meaningful differences without conscious awareness

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In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

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processing the same transcript to exclude exon 4 produces a mRNA that encodes the precursor for CGRP

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