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A truncated 67-aa IGF-1 analog lacking the N-terminal Gly-Pro-Glu tripeptide, with higher intrinsic IGF-1R affinity and moderately reduced IGFBP binding

Current Pharmaceutical Design, 24 (18), 19902001

In the Phase 2 trial, GI side effects were dose-dependent and generally mild to moderate in severity

While more studies, especially on humans, are still underway, the existing evidence suggests it could potentially speed recovery from injuries both minor and severe

it is instead a twincretin, meaning it activates two receptorsGLP-1 and GIPand is currently marketed as Mounjaro and Zepbound

Semaglutide lowers body weight by reducing appetite and hunger, increasing satiety, reducing food cravings, altering food preferences, and reducing energy intake