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In animal reproduction studies, administration of subcutaneous insulin aspart to pregnant rats and rabbits during the period of organogenesis did not cause adverse developmental effects at exposures 8-times and equal to the human subcutaneous dose of 1 unit/kg/day, respectively

doi: 10.3389/fnut.2025.1524125 Received 07 November 2024 Accepted 02 January 2025 Published 17 January 2025 Volume 12 - 2025 Edited by Xiaoyong Yu, Shaanxi Provincial Hospital of Traditional Chinese Medicine, China Reviewed by Fahd Beddar, Universidad de Valladolid, Spain Updates Copyright 2025 Eliopoulos, Gkouskou, Tsioufis and Sanoudou

A higher dose might slightly shorten the onset time, but it disproportionately increases the risk of unwanted side effects like nausea and headaches

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