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The direction of HbA1c distortion in B12 deficiency is variable and cannot be assumed to be consistently high or low

Patients with megaloblastic anemia may experience hypokalaemia and sudden death if they are given intensive treatment with cyanocobalamin (vitamin B12)

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In such cases, the subject still technically has PD, but the quality of life of the subject is significantly improved because the progression of symptoms is slowed, or even stopped (arrested) at an earlier stage than would be possible without administration of the HGF mimic(s), e.g