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Compared with previous reviews published over the past two years, this analysis focused specifically on studies involving patients who already had both type 2 diabetes and PAD at study entry

I understand your question is about anxiety specifically, but I wanted to share the broader research thats been done so far

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A meta-analysis reported a pooled risk ratio of 2.83 for continuous abstinence at 52 weeks compared with placebo [] , while a network meta-analysis similarly found that varenicline nearly doubled the likelihood of sustained cessation []