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In paediatric and adult populations, FIC-related variants may result in HCC and CCA, especially for ABCB11 (about 515% of children with PFIC2 develop HCC in their second- third year of life) [9, 70], ABCB4 [15] and TJP2 [9]

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To determine the contribution of the tendon-derived ExtraMito particles within mEP 9%, which act as a chemoattractant to RAW 264.7 cells, we first depleted mitochondria from mEP 9% using the TOM20 antibody via MACS technology (Fig