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Neither pill matches the potency of the injectable GLP-1 therapies, which can produce 15 to 21 percent weight reduction

DOI: 10.1056/NEJMoa2307563 Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

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For example, the SELECT trial clearly demonstrated that semaglutide significantly reduces the risk of major adverse cardiovascular events (MACE), leading to FDA approval for lowering the risk of cardiovascular death, myocardial infarction, or stroke in overweight or obese adults with established cardiovascular disease (Marso et al., 2016a)

doi: 10.1192/j.eurpsy.2025.1993

A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference