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Symptoms, Causes, Diagnosis, Treatment, and Prevention Signs and Symptoms of COPD Persistent cough that may contain mucus, referred to as smokers cough. Chest tightness Wheezing Dyspnea, or shortness of breath that worsens with activity Fatigue Weight loss Swelling of the feet and ankles, called edema Blueness of the skin, lips, and fingernails, called cyanosis Mental confusion or disorientation People with COPD often experience flare-ups, or periods of time when symptoms worsen

Abbreviations: GLP-1 RA GLP-1 receptor agonist(s)