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Like LNPs, polymeric NPs also encapsulate the Cas9 and gRNA

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IKK activity is triggered during aging by NF-B (Kim et al., 2002), which further modulates the p38 MAPK, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinases (JNKs) pathways that modulate the NF-B-dependent transcriptional activity during the inflammatory reaction