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Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels

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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Canale M.P., Manca di Villahermosa S., Martino G., Rovella V., Noce A., De Lorenzo A., Di Daniele N

Human research is limited, though animal data is robust and consistent across multiple models

These include primary enzymatic defenses such as superoxide dismutase and glutathione peroxidase [21,22]