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5 The annual incidence ranges from 8.8 to 23.1 per 100,000 person-years in North America, 0.624.3 per 100,000 person-years in Europe, and 7.317.4 per 100,000 person-years in Oceania, with a prevalence in adults in their 30 s and 40 s

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Plaintiffs argue that these medications can lead to gastroparesis, intestinal blockages, and persistent vomiting, and that manufacturers failed to provide adequate warnings about these risks

doi:10.1038/s41591-022-02026-4 Geer JH, Hilbert J

In conclusion, the underlying pathophysiological mechanism remains uncertain

However, these patients had multiple risk factors for b12 deficiency beyond semaglutide use, including previous gastric surgery that permanently alters stomach anatomy and reduces intrinsic factor production