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Large oncosome-loaded VAPA promotes bone-tropic metastasis of hepatocellular carcinoma via formation of osteoclastic pre-metastatic niche

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The ACHIEVE-3 trial demonstrated that orforglipron was superior to oral semaglutide (Rybelsus) in both HbA1c reduction and weight loss in a head-to-head comparison, reducing HbA1c by approximately 2.2 percentage points versus 1.4 points with oral semaglutide, and producing 9.2% weight loss versus 5.3%

In lean mice, a long-acting GIPR agonist increased OL lineage cells and myelin in the ME

ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance

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