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4.2 Neuronal energy deficiency and cognitive decline Mitochondrial dysfunction and insufficient energy supply in the central nervous system may lead to inadequate ATP production, which in turn may affect neuronal synaptic transmission efficiency and excitability, particularly impairing the function of high-energy-demand brain regions such as the prefrontal cortex, hippocampus, and basal ganglia (158, 159)

The code has been developed and tested using Python 3.5 on Linux operating system and is available under the MIT license

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Although the committee's recommendations often carry significant weight in the FDA's decision-making, they are advisory rather than binding

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The purity of each batch is verified by HPLC (min