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Transport proteins serve as crucial hubs in uric acid metabolism, and inhibitors targeting these proteins, particularly those involved in reabsorption, have long been one of the most important therapeutic approaches for managing hyperuricemia

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The nausea, digestive discomfort and fatigue that many people experience in the early weeks of treatment often return, usually in a milder form, when the dose increases

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This exposure leads to darkening of the skin, commonly observed on areas such as the face, arms, hands, legs, feet, back, and neck

Diarrhea is the second most common gastrointestinal side effect after nausea, which affects approximately 40% of patients