Glutathione (GSH) is a liver-produced antioxidant made from amino acids (cysteine, glutamic acid, and glycine), which neutralizes free radicals, promotes detoxification, and repairs cell damage
10.1016/j.gene.2020.145134 82 LiY.XiaoX.WangH.ZhouQ.JinZ.ZhangY.et al (2021b)
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Burgeoning evidence also suggest that metabolic dysregulations in ADPKD involve abnormal mitochondrial morphology and function and facilitates cyst formation, as seen in increased vacuolated and fragmented mitochondria in PKD1 / mutant renal epithelial cell lines, mouse and human kidneys and decreased viability and exercise endurance along with increased carbon dioxide production (Ishimoto et al., 2017