The appetite feedback circuit: how GLP-1 medications change the equation Here is where the science gets genuinely interesting, and where GLP-1 medications demonstrate their remarkable advantage over traditional dieting
Signs of dehydration include decreased urine output, dark urine, dizziness, and dry mouth
GLP-1 receptor agonists typically increase resting heart rate by 2-4 beats per minute on average, though some patients experience increases of 10 beats per minute or more
There have been plenty of studies on older, less powerful drugs in the GLP-1 class, such as liraglutide, but semaglutide and tirzepatide represent new territory
QTc interval prolongation was studied in a randomized, placebo-controlled parallel trial in 116 healthy subjects who received either chloroquine (1000 mg) alone or in combination with azithromycin (500 mg, 1000 mg, and 1500 mg once daily)
Tirzepatide is still at 2.5mg, its sub-therapeutic starting dose, and hasn't reached the levels that drive meaningful appetite suppression