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doi: 10.3389/fimmu.2025.1614304 Received 18 April 2025 Accepted 07 July 2025 Published 29 July 2025 Volume 16 - 2025 Edited by Lindsay B Nicholson, University of Bristol, United Kingdom Reviewed by Liping Du, The First Affiliated Hospital of Zhengzhou University, China Timothy Janetos, Northwestern Medicine, United States Jarmila Heissigerova, Charles University, Czechia Chaokui Wang, Chongqing Eye Institute, China Updates Copyright 2025 Liu, Geng, Liu and Liu

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Implications for stepped-care personalization Several phenotyping frameworks now assist clinical decision-making by enabling clinicians to customise treatment according to each patients biological profile