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Bimagrumab is a first-in-class monoclonal antibody that targets activin type II receptors (ActRII), promoting muscle preservation and growth

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In NEMO-deficient endothelial cells, the expression of cytokines (such as IL-1, IL-6, and TNF-) and chemokines (such as MIP-1 and MCP-1) is reduced, and the infiltration of macrophages and T lymphocytes into atherosclerotic plaques is also significantly decreased [139]