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The mechanism involves slowing gastric emptying, increasing satiety signals, and modulating insulin and glucagon secretion - which together contribute to the appetite regulation and weight management effects associated with this drug class

The additional GIP receptor agonism may contribute to retatrutide's greater weight loss

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( D ) Islets immunostained for insulin (red), glucagon (green), and DAPI

Residential programs originally designed for alcoholism found many patients developed severe overeating and substantial weight gain after detoxification