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Labelling cLip-1 in mouse tissues revealed its accumulation in the kidney, colocalizing with a lysosomal marker in renal proximal tubules (Fig

Conclusion: The hepatocyte-specific deletion of EGFR alters lipid metabolism and fibrosis signaling in a murine FFD model of NAFLD, but is much less effective compared to pharmacological inhibition of EGFR

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to regularly evaluate renal function

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The American Diabetes Association (ADA) Standards of Care emphasize individualized therapy selection, with GLP-1 receptor agonists considered preferred agents for many patients with type 2 diabetes who require additional glucose-lowering therapy beyond metformin, particularly those with established cardiovascular disease or chronic kidney disease

Under hyperglycemic conditions, Mller cells experience oxidative stress, inflammation, and mitochondrial dysfunction, leading to neuronal damage and neuroinflammation (202205)