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The 2026 American College of Physicians living clinical guideline placed both semaglutide and tirzepatide as conditional first-line recommendations for obesity, citing the evidence base and noting the need for shared decision-making on benefits, harms, and access [11]
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Other important side effects include gallbladder disease (cholelithiasis, cholecystitis), and potential worsening of diabetic retinopathy (particularly with rapid HbA1c reduction on semaglutide)
PMID: 36566341
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