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Larger sustained increases warrant a clinician check

If you know or suspect your tirzepatide has been exposed to temperatures outside the 36-86F range, or if an unopened pen/syringe has been at room temperature for more than 21 days, the medication should be discarded regardless of appearance

One detail that trips people up: the "unit" markings on an insulin syringe are calibrated for U-100 insulin, meaning 100 units per milliliter

The real cost savings, if any, come from two scenarios

This is also the highest dose that was studied in the SURPASS and SURMOUNT trials

However, if you are also taking sulfonylureas or insulin, adding even a microdose of tirzepatide could push blood glucose too low