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Fatigue and Cognitive Impairment First-generation antihistamines (like diphenhydramine/Benadryl and hydroxyzine) are notorious for causing drowsiness because they cross the blood-brain barrier and block H1 receptors in the central nervous system

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Owing to its unique enzymatic properties, GPx-4 activity can be separately determined using a phospholipid hydroperoxide substrate in enzymatic assays (386)

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Increased intracellular calcium inhibits enzymes responsible for the distribution of phospholipids in plasma membranes and the release of cytochrome C and apoptosis-inducing factors, triggering neuronal apoptotic death, suppressing neurotransmission, and cognitive dysfunction (Bezprozvanny and Mattson 2018)

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