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Hubbard, T

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In gouty arthritis, the intraarticular deposition of monosodium urate crystals activates the NLRP3 inflammasome, leading to the secretion of proinflammatory cytokines, including IL1, which mediate acute inflammatory responses

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This structural formula has an unusual peptide bond, usually processed from glutamate to -carboxyl group (-COOH) has a close relationship with cysteine alpha - a peptide bond made by the contraction of amino -(-NH2)