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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility
There have been numerous cases of alcohol poisoning and death in this range of BAC
Potential Broader Physiological Roles of DSIP Initially identified in rabbit brains during slow-wave sleep, DSIP is linked to sleep regulation and CNS modulation of sleep-wake cycles
doi: 10.2147/vhrm.s4891
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