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[2] DPP-4 inhibitors (such as sitagliptin or linagliptin) enhance the body's own GLP-1 levels by preventing its breakdown, though they are less potent than GLP-1 agonists for glucose control and weight loss

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It blunts that craving that pulls people toward whatever they're addicted to." Targeting the Biology of Craving Al-Aly said the study was partly inspired by patient reports describing unexpected changes in behavior after starting GLP-1 treatment

In a combination protocol, some researchers theorize that starting at a lower dose (1mg daily) and assessing tolerance before escalating to the full 2mg might reduce the risk of compounding side effects with retatrutide

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Chem Biol Interact 2013