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Although negative findings that are in contrast to other combinatorial pharmacotherapy that additively reduces alcohol drinking (Zhou et al., 2019

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Risk-of-bias assessment The methodological quality of included RCTs was assessed utilizing the Cochrane Risk of Bias 2 (RoB2) tool [18], while observational studies were evaluated with the Risk Of Bias In Non-randomized Studiesof Interventions (ROBINS-I) [19]