On the other hand, the use of animal models to study invasive meningococcal disease, in addition to presenting the obvious difficulties in investigating aspects of the extracellular/intracellular phase of meningococcal infection, is hampered by the fact that meningococcus has a very narrow host specificity, essentially restricted to humans
10 Diabetic retinopathy (DR), occurred in 22% of diabetes patients and 6% suffer from vision threatening DR which might lead to irreversible vision impairment even blindness
Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig
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