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For nasal sprays where the generic has the same formulation as the RLD, the FDAs 2003 BA/BE guidance specifies eight in vitro tests: Single Actuation Content (SAC/SCU)

GLP-1 verstrkt die glukoseabhngige Insulinsekretion, das heit, seine Wirkung nimmt zu, wenn die Glukosekonzentration nach einer Mahlzeit steigt, whrend gleichzeitig die Glukagonfreisetzung unterdrckt wird

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J Transl Med 10(1):11