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Binding studies in CHO-K1 cells expressing GLP-1R showed that lixisenatide is a potent and selective GLP-1RA, with a binding affinity to GLP-1R approximately four times greater than that of GLP-1 (88)
Pyroglutamic acid Pyroglutamic acid (also known as PCA , 5-oxoproline , pidolic acid ) is a ubiquitous but understudied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam
Zhou QM, Zhang H, Lu YY, Wang XF, Su SB
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Erst mit der Entwicklung von dualen Agonisten wie Tirzepatid, das neben dem GLP-1-Rezeptor auch den GIP-Rezeptor aktivieren kann (17), wurde das Interesse an GIP wiederbelebt