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The FDA-approved dose escalation timeline The FDA-approved semaglutide dosing schedule for weight management (Wegovy) follows a gradual escalation over 16 weeks before reaching the maintenance dose: This gradual approach exists for a critical reason

Semaglutide has a half-life of 165 hours compared to 13-15 hours of liraglutide

Tirzepatide typically results in greater weight loss and appetite control

This adaptation pattern is one reason consistency with your injection schedule matters

Persistent nausea lasting more than 2 weeks after a dose increase warrants stepping back to the previous dose for 2 to 4 additional weeks before trying again

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