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For membrane-associated receptors, the former predominantly exists in adrenal medulla, renal pelvis, and ovary (28)

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The hallmarks of aging a framework established by Lpez-Otn and colleagues and updated through subsequent research include telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, cellular senescence, and dysregulated nutrient sensing, among others.1 Each hallmark represents a distinct biological failure mode