12.31.23 2023 year-end total adverse events 2023 year-end total adverse events: A total of 1,322 cases, including 598 serious cases and 19 deaths
This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
950.37, crude fat - method no
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Magnesium and Fertility The role of magnesium in over 300 enzymatic processes including those critical to egg development and implantation
Wireless motility capsules and multi-omics showed substantial daily fluctuations in transit times and luminal pH among healthy individuals, and provided explanations for differences in gut microbiome metabolites
