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Efficacy of a novel hydroquinone-free skin-brightening cream in patients with melasma

Biochemically, due to intracellular GSH deprivation and GPX4 deactivation, lipid peroxides derived from Fe2+-catalyzed Fenton reaction fail to be eliminated through the GPX4-mediated reduction reaction, producing abundant reactive oxygen species (ROS), which facilitates ferroptosis (Stockwell et al., 2017

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Likewise, monopotassium glutamate (MPG) is the potassium salt of glutamate