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This disorder is associated with mitochondrial abnormalities of respiratory function, Ca 2+ cycling, ROS/RNS production, mPTP opening, activation of different mechanisms of programmed cell death, disbalance of the processes of mitochondrial fusion, fission, and autophagy, and disturbances in synaptogenesis and synaptic transmission which affect the brain development and cause behavioral deficits

Handlers are advised to consult the relevant literature on both compounds to determine potential interactions [13]

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For instance, C16:0 and C2:0-ceramides might increase the permeability of mitochondria membranes releasing cytochrome c tentatively by channel formation (Siskind and Colombini, 2000)

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doi:10.1016/j.bbamcr.2015.01.021