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Unfortunately, she says, theres no good evidence that GLP-1s, especially the newer drugs like Mounjaro, actually improve ovulation or pregnancy odds in people with PCOS

Clinical use shows HbA1c reductions often exceeding 1 percent from baseline, and these agents are recommended for patients not meeting glycemic targets with first-line therapy

These factors indicate that the GLP-1 RA group is more severely affected by diabetes compared to the DPP-4i group, and the GLP-1 RA group may thus be subject to residual confounding associated with higher fracture risk

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[2] [1] These findings led to regulatory warnings and precautions that remain in place today