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Mechanistically, as noted earlier, the fading of gastric symptoms over time is at least consistent with partial adaptation of the gastric-emptying effect, though symptom reports are an imperfect proxy for the underlying motility

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10.1016/j.jep.2021.114108

Other protoberberine alkaloids in FRP, such as palmatine, jatrorrhizine, and columbamine could also show a moderate binding affinity with core target proteins

They activate different second messenger systems