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GAN DIO-NASH-HCC mice showed significant expansions in myeloid immune cell populations (CD45 + CD11b + ), dominated by increased number of cells with high expression of Ly6C (Ly6C ++ ), a signature of infiltrating inflammatory monocytes/macrophages 27 , resident Kupffer-like macrophages (F4/80 low CD11c high ) and dendritic-like cells (F4/80 high CD11c low ) 27 , with reciprocal reductions in Ly6G + neutrophils

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While general gastrointestinal issues like nausea are common, severe inflammation of the stomach lining is reported much less frequently in 2026 clinical data

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